Question

Which one of these are correct Michaelis-Menten equation?

(a) –dC/dt = Vmax C/Km+C

(b) dC/dt = Vmax C/Km+C

(c) –dC/dt = Vmax C/Km

(d) –dC/dt = Km+C/Vmax C

The question was asked during an online exam.

Query is from Non Linearity of Drugs in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right option is (a) –dC/dt = Vmax C/Km+C

To explain: The kinetics of capacity-limited or saturation process is described by Michaelis-Menten equation, the equation is –dC/dt = Vmax C/Km+C, where –dC/dt = rate of decline of drug concentration with time, Vmax is the theoretical maximum rate of the process and Km is Michaelis constant.