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Clearance is inversely related to volume of distribution.

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in Drug Biotechnology by (138k points)
Clearance is inversely related to volume of distribution.

(a) True

(b) False

This question was posed to me in an international level competition.

The question is from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

1 Answer

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Correct choice is (a) True

The best I can explain: The clearance decreases when a drug has a large volume of distribution. A drug with large Vd is poorly excreted in urine. Blood restricted to blood compartments have higher excretion rates.

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