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What is total systemic clearance?

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in Drug Biotechnology by (138k points)
What is total systemic clearance?

(a) Sum of clearance from kidney

(b) Sum of clearance from kidney and liver

(c) Sum of clearance form non-renal clearances

(d) Sum of renal and non-renal clearances

I got this question by my school principal while I was bunking the class.

My question is from Drugs Excretion in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

1 Answer

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by (1.1m points)
Correct option is (d) Sum of renal and non-renal clearances

Easiest explanation: The sum of individual clearances by all eliminating organs is called total body clearance or total systemic clearance. It is expressed as the sum of renal and non-renal clearance. This term is applied to all organs involved in drug elimination.

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