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Which caspase is activated in the ER pathway of apoptosis?

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in Cytogenetics by (679k points)
Which caspase is activated in the ER pathway of apoptosis?

(a) Caspase 3

(b) Caspase 7

(c) Caspase 8

(d) Caspase 12

This question was addressed to me in an online interview.

The origin of the question is Apoptosis and Cancer in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

1 Answer

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Best answer
Right option is (d) Caspase 12

Best explanation: In extreme hypoxic conditions, the TRAF2 in the ER releases the associated procaspase 12; activated caspase 12 and leads to apoptosis.

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