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Which CDK triggers origin firing?

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Which CDK triggers origin firing?

(a) G1

(b) G1-S

(c) S

(d) M

I had been asked this question by my school teacher while I was bunking the class.

This intriguing question comes from Cell Cycle Stages topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics

1 Answer

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Best answer
Correct choice is (c) S

The explanation: S CDK phosphorylates the residues on MCM and on ORC thus triggering ORC firing leading to DNA replication in the cell. ORC is fired once and only once during cell cycle.

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