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In mice the expression of Igf2 and H199 is only controlled by methylation.

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In mice the expression of Igf2 and H199 is only controlled by methylation.

(a) True

(b) False

I had been asked this question in homework.

The doubt is from Silencing and Genomic Imprinting topic in section Regulating Gene Expression in Eukaryotes of Cytogenetics

1 Answer

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Right answer is (b) False

The best explanation: In addition to methylation the control is achieved by the presence of an insulator CTCB that helps by preventing the enhancer interaction of Igf2 in the maternal chromosome.

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