Right option is (a) True
The best I can explain: Age, sex, species and strain difference, differences in the genetic make-up, circadian rhythm, etc. alter drug excretion. Renal excretion is 10% lower in females than in males. The renal function of new-borns is 30 to 40% less than adults and attains maturity between 2.5 to 5 months of age.