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What is the mechanism of drug excretion for skin excretion?

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What is the mechanism of drug excretion for skin excretion?

(a) Active secretion

(b) Glomerular secretion

(c) Passive diffusion

(d) Passive reabsorption

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This key question is from Drugs Excretion topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

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Correct answer is (c) Passive diffusion

Explanation: Passive excretion of drugs occurs through the skin. In the case of excretion through the skin, drugs follow pH partition hypothesis. Free, unionized, lipophilic drugs can passively be diffused into the sweat.

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