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What is the molecular weight cut off for biliary excretion?

(a) Less than 300 Dalton

(b) More than 300 Dalton

(c) Less than 200 Dalton

(d) More than 200 Dalton

This question was addressed to me in an interview for job.

My question is based upon Drugs Excretion in section Prodrugs & Excretion of Drugs of Drug Biotechnology

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Correct answer is (b) More than 300 Dalton

Explanation: The threshold is 300 Dalton for biliary excretion. The threshold if 300V or greater than 300 Dalton is necessary for the excretion of organic cations and anions respectively. Non-ionic compounds must be highly polar for excretion.

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