Question

What is the end product of hydrolysis of Lidocaine?

(a) 2, 6-Xylidine, N, N-Dimethylglycine

(b) 2, 5- Xylidine, Dimethylglycine

(c) Xylidine, glycine

(d) 1, 6-Xylidine

This question was posed to me in exam.

Question is taken from Drugs Biotransformation in chapter Biotransformation of Drugs of Drug Biotechnology

Answer 1

Correct choice is (a) 2, 6-Xylidine, N, N-Dimethylglycine

Explanation: The reaction of hydrolysis of amides is catalysed by amidases. Lidocaine is a secondary amide with an organic substituent on N-atom. Thus providing us with 2, 6-Xylidine, N, N-Dimethylglycine as the end product.