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Which enzyme’s presence is of utmost importance for the 2nd step of sulphation?

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Which enzyme’s presence is of utmost importance for the 2nd step of sulphation?

(a) Sulfotransferase

(b) Amidases

(c) Transferase

(d) UDP-glucuronyl transferase

This question was addressed to me in an internship interview.

This intriguing question comes from Drugs Biotransformation in section Biotransformation of Drugs of Drug Biotechnology

1 Answer

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Right choice is (a) Sulfotransferase

The best explanation: Sulfotransferase catalyses the transfer of sulphate group from 3’-phosphoadenosine-5’-phosphosulfate to the substrate. It also helps in the liberation of 3’-phosphoadenosine-5’-phosphate.

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