Question

Which drug accumulate in adipose tissue?

(a) Arsenicals

(b) Tetracycline

(c) Halogenated hydrocarbons

(d) Lipophilic drug

The question was asked in an interview for internship.

The query is from Tissue Binding of Drugs topic in section Protein Binding of Drugs of Drug Biotechnology

Answer 1

The correct answer is (d) Lipophilic drug

To explain I would say: Lipophilic drugs such as that of thiopental and pesticides such as DDT accumulate in adipose tissue. Halogenated hydrocarbon and paracetamol bind irreversibly to the liver tissues resulting in hepatotoxicity. Tetracycline tends to bind to bones and teeth.