Question

Which of the following is an example of a mutual prodrug?

(a) Prontosil is the prodrug for sulfanamide

(b) Aspirin is the prodrug of salicylic acid

(c) Benorylate prodrug for NSAIDs and paracetamol

(d) Diesters pro-prodrug for pilocarpic acid

The question was asked in class test.

Origin of the question is Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer 1

The correct answer is (c) Benorylate prodrug for NSAIDs and paracetamol

For explanation: Mutual prodrug is pro-drugs comprising of 2 pharmacologically active agents coupled together to form a single product. Thus, benorylate prodrug for NSAIDs and paracetamol is an example of mutual prodrug.