Question

What is the function of a flavoprotein, located in the endoplasmic reticulum?

(a) Oxidising the substrate

(b) Reducing the cytochrome-450 to the ferrous form

(c) Facilitate electron transfer from NADPH to cytochrome 450

(d) Facilitate electron transfer from cytochrome 450 to NADPH

This question was posed to me during an internship interview.

My question is based upon Drugs Biotransformation in chapter Biotransformation of Drugs of Drug Biotechnology

Answer 1

Correct option is (b) Reducing the cytochrome-450 to the ferrous form

The explanation: Flavoprotein functions as an electron carrier and catalyses the reduction of cytochrome 450 to ferrous form by transferring an electron from NADPH. Flavoprotein in multienzyme mixed-function oxidase system.