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Which of the following is not a physicochemical factor of drug that can affect the renal excretion?

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Which of the following is not a physicochemical factor of drug that can affect the renal excretion?

(a) Molecular size

(b) Disintegration rate

(c) pKa of the drug

(d) Lipid solubility

The question was asked in an online quiz.

Question is taken from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

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Right answer is (b) Disintegration rate

To elaborate: Important physicochemical factor that has effect on the renal excretion are molecular size, pKa of the drug, and lipid solubility. A small molecular sized compound can easily get filtered out by the glomerulus. Compounds of eight below 300 Dalton and water soluble, can get readily excreted by glomerulus. Disintegration rate does not affect the excretion, it will affect absorption.

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