Question

What is the optimal multiple dosage regimen?

(a) The concentration of active agent in the drug formulation

(b) Dosage which maintains the plasma concentration within the therapeutic window.

(c) The manner in which a drug is taken

(d) The manner in which drug given to child

I have been asked this question in an international level competition.

My question is from Pharmacokinetic Principles Applications topic in chapter Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Correct choice is (b) Dosage which maintains the plasma concentration within the therapeutic window.

The explanation: When the drug is administered in suitable doses with sufficient frequency to ensure that a stable plasma concentration is maintained which will be within the therapeutic window for the entire duration of therapy is known as optimal multiple dosage regimen. Drugs such as antibiotics a minimum effective concentration has to be maintained for all time till the patient heals.