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Which of the following is the shortest acting fentanyl analogue?

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Which of the following is the shortest acting fentanyl analogue?

(a) Alfentanyl

(b) Sufentanil

(c) Remifentanil

(d) Carfentanil

This question was posed to me in an interview for internship.

This interesting question is from Opioid Analgesics topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct option is (c) Remifentanil

To elaborate: Remifentanil, currently the shortest acting opioid, has the benefit of rapid offset, even after prolonged infusions. Alfentanil, ultra-short acting i.e. 5-10 minutes analgesic. Sufentanil, a potent analgesic 5 to 10 times more potent than fentanyl for use in heart surgery. Carfentanil is used in veterinary practice.

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