Question

Macrophages with a high content of EPA produce less TNF and IL-l.

(a) True

(b) False

I had been asked this question during an interview for a job.

This intriguing question originated from Drug Addiction and Abuse in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer 1

Right choice is (a) True

The best explanation: EPA is found in fish oil. It acts as a substrate for cyclooxygenases and lipoxygenases. The prostaglandins, thromboxanes, and leukotrienes produced from EPA are less active than AA metabolites. These products then compete with products of AA metabolism for shared target receptors. Macrophages with a high content of EPA produce less TNF and IL-l. Dietary EPA supplementation can reduce tissue injury due to PGs, TXs, LTs, and cytokines.