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Which of the following has the same potency as ASA and better tolerated by patients?

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Which of the following has the same potency as ASA and better tolerated by patients?

(a) Piroxicam

(b) Phenylbutazone

(c) Ibuprofen

(d) Indomethacin

The question was asked in class test.

The doubt is from Drug Addiction and Abuse in portion Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

1 Answer

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Best answer
Right choice is (c) Ibuprofen

To explain: Ibuprofen is a propionic acid derivative has the same potency as acetyl Salicylate but better tolerated since it has fewer side effects. Thus most of the times ibuprofen is mostly prescribed. Indomethacin is an indole derivative more potent than ASA but inferior at doses tolerated by rheumatoid arthritis patients, quite toxic.

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