Question

On what basis the dose interval is calculated?

(a) Active drug concentration in the formulation

(b) Half-life of the drug

(c) Duration of the disease

(d) Age of the patient

The question was posed to me in quiz.

I need to ask this question from Pharmacokinetic Principles Applications topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Correct answer is (b) Half-life of the drug

To elaborate: Any dose frequency is being calculated on the basis of half-life of the drug. If the interval is increased without changing the dose, Cmax, Cmin, Cav decreases but the ratio of Cmax/Cmin increases. Opposite can be observed if dosing interval is reduced frequency increased. It can also result in accumulation and toxicity.