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What is fluctuation?

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What is fluctuation?

(a) Cmax/Cmin

(b) Cmin / Cmax

(c) 1/Cmin

(d) 1/Cmax

The question was asked during an interview.

This is a very interesting question from Pharmacokinetic Principles Applications topic in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

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The correct choice is (a) Cmax/Cmin

The best I can explain: Fluctuation is defined as the ratio between Cmax and Cmin. Greater the ratio greater fluctuations will be seen in the graph. Fluctuations depend upon the dosing frequency and half-life of the drug. It also depends upon the rate of absorption. Greatest fluctuation can be seen when the drug is administered as a i.v. bolus.

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