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Which of the following is the first antihistamine?

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in Drug Biotechnology by (138k points)
Which of the following is the first antihistamine?

(a) Piperoxan

(b) Ethylenediamine

(c) Alkylamines

(d) Tricyclics

The question was asked during an internship interview.

The question is from Drug Concentration and Pharmacologic Response topic in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

1 Answer

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Right answer is (a) Piperoxan

To elaborate: Piperoxan is discovered in 1933 by Jeff Forneau and Daniel Bovent while developing a guinea pig animal model of anaphylaxis. They received the Nobel Prize in 1957. Classes of first-generation H1 receptor antagonist antihistamines are ethylenediamines, ethanolamines, alkylamines, piperazines, tricyclics.

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