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Synthesis of histamine needs the enzyme histidine decarboxylase.

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Synthesis of histamine needs the enzyme histidine decarboxylase.

(a) True

(b) False

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This intriguing question originated from Drug Concentration and Pharmacologic Response in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

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Correct choice is (a) True

The best explanation: Histamine, when released, causes inflammation by increasing vasodilation, capillary permeability, causing smooth muscle contraction, mucus secretion, and parasympathetic nerve stimulation. Formed from the amino acid Histidine in a decarboxylation reaction with the enzyme histidine decarboxylase. Occurs primarily in mast cells and basophils.

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