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Which of the following is a long-acting insulin analogue?

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Which of the following is a long-acting insulin analogue?

(a) Lispro

(b) Insulin aspart

(c) Glulisine

(d) Glargine

The question was asked in an online quiz.

My query is from Controlled Release Medication topic in section Controlled Release Medication of Drug Biotechnology

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The correct choice is (d) Glargine

To elaborate: Glargine is manufactured by Aventis Pharmaceuticals and is marketed under the brand name Lantus. Insulin glargine has a substitution of glycine for asparagine at A21 and two arginines added to the carboxy terminal of B chain. Thus its name is gl-arginine.

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