Question

What are the characteristics of osmotic pressure-controlled systems?

(a) Buffering agents that adjust pH to the desired value

(b) Releases the drug at a zero-order kinetics

(c) Hollow systems containing drug surrounded by a polymer membrane

(d) Formation of complexes between the drug and anion/cation exchange resins

I have been asked this question during an interview.

The question is from Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology

Answer 1

Right option is (b) Releases the drug at a zero-order kinetics

To explain I would say: Osmotic pressure-controlled systems works on the principle of osmotic pressure to release the drug at a constant zero order rate. The core of the system comprises of the drug and osmotically active substance which will be surrounded by a rigid semipermeable membrane coating.