Question

Larger particle size leads to ____________ dissolution.

(a) Slower

(b) Faster

(c) Moderate

(d) Normal

This question was addressed to me in an online interview.

The origin of the question is Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology

Answer 1

Right option is (a) Slower

Easy explanation: Larger the particle size slower the dispersion since the surface area to volume ratio is less. Although large particles have their own disadvantages such as causing irritation at the injection site, poor syringeability and injectability, and rapid sedimentation. We can use viscosity builder but this also retards drug diffusion.