Question

What are the characteristics of the mixed monolithic-reservoir devices?

(a) The drug has a large therapeutic index

(b) Drug permeation rate is high

(c) The drug-polymer matrix is layered by rate-controlling membrane

(d) Administration of emulsions

I got this question by my college professor while I was bunking the class.

The above asked question is from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology

Answer 1

Right answer is (c) The drug-polymer matrix is layered by rate-controlling membrane

The explanation: This device has drug release kinetics intermediate between monolithic and reservoir systems. Here the drug-polymer matrix is layered by a rate controlling membrane. The release is controlled initially by the membrane but as the drug gets depleted the rate is controlled by diffusion of the drug.