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Which of the following do not incorporate in the genome and replicates in the cytoplasm?

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Which of the following do not incorporate in the genome and replicates in the cytoplasm?

(a) Poxvirus

(b) Baculovirus

(c) Adenovirus

(d) Retrovirus

This question was posed to me in an interview for internship.

I'd like to ask this question from Genetic Recombination topic in section Genetic Recombination of Drug Biotechnology

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Correct option is (a) Poxvirus

Easy explanation: Poxvirus/ vaccinia virus does not get incorporated into the genome of the host cell. They reside in the cytoplasm and replicate in the cytoplasm. Thus, they help in transient transformation rather than permanent transformation. The genome size of pox/ vaccinia virus is 300 kb.

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