Question

Which of these are the possible cause of sickle cell anemia with respect to hemoglobin:

(a) Defect in β-chain of hemoglobin

(b) Defect in α-chain of hemoglobin

(c) One copy of an abnormal β-globin gene

(d) Two copies of an abnormal β-globin gene

This question was addressed to me in my homework.

The above asked question is from Fibrous and Globular Proteins in division Biomolecules and Catalysis of Life Sciences

Answer 1

Right option is (d) Two copies of an abnormal β-globin gene

For explanation: If a person has one copy of abnormal β-globin gene it will show sickle cell trait but not sickle cell anemia while an individual with sickle cell anemia has both the copies of an abnormal β-globin gene.