Question

Which of the following least describes Long Loop β-hairpins?

(a) They are Often referred to as a ‘random coil’ conformation

(b) Generally they are referred to as the β-meander supersecondary structure

(c) Loop looks similar to the Greek Letter Ω

(d) Wide-range of conformations with very specific sequence preferences

The question was posed to me in a job interview.

I need to ask this question from Protein Motifs and Domain Prediction in section Sequence Alignment of Bioinformatics

Answer 1

The correct option is (d) Wide-range of conformations with very specific sequence preferences

The explanation: They are wide-range of conformations with no particular sequence preferences. As the name suggests ‘meander’ the conformation they possess is also quite unspecified. Addition to that Long loop β-hairpins are special case of Ω loops, that explains a lot about their structural preferences.