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On average, what is the length of a typical domain?

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On average, what is the length of a typical domain?

(a) About 100 residues

(b) About 300 residues

(c) About 500 residues

(d) About 900 residues

The question was asked in homework.

Origin of the question is Protein Motifs and Domain Prediction in chapter Sequence Alignment of Bioinformatics

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Best answer
Correct option is (a) About 100 residues

Best explanation: The predicted optimal number of residues, which corresponds to the maximum free energy of unfolding, is 100. This is in agreement with a statistical analysis derived from their experimental structures of motifs. For too short chain, change in enthalpy of internal interactions is not favorable enough for folding because of the limited number of inter-residue contacts. And a long chain is also unfavorable for a single domain.

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