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In local alignment, the two sequences to be aligned cannot be of unequal lengths.

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In local alignment, the two sequences to be aligned cannot be of unequal lengths.

(a) True

(b) False

The question was asked in unit test.

Origin of the question is Methods topic in portion Pairwise Sequence Alignment of Bioinformatics

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Correct option is (b) False

The best explanation: The two sequences to be aligned can be of different lengths. This approach is more appropriate for aligning divergent biological sequences containing only modules that are similar, which are referred to as domains or motifs. This approach can be used for aligning more divergent sequences with the goal of searching for conserved patterns in DNA or protein sequences.

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