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In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.

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In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.

(a) True

(b) False

This question was addressed to me in an interview for internship.

My question is based upon Performance Evaluation topic in division RNA Structure Prediction of Bioinformatics

1 Answer

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Best answer
Right option is (a) True

Easiest explanation: The alignment is produced using dynamic programming with a scoring scheme that incorporates sequence similarity as well as energy terms. Because the full dynamic programming for multiple alignment is computationally too demanding, currently available programs limit the input to two sequences.

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