Question

The pre-alignment independent programs fare __________ for predicting long sequences.

(a) slight better

(b) much better

(c) a bit worse

(d) much worse

This question was posed to me during an interview for a job.

The query is from Performance Evaluation topic in division RNA Structure Prediction of Bioinformatics

Answer 1

Correct answer is (d) much worse

To explain I would say: For small RNA sequences such as tRNA, both subtypes can achieve very high accuracy (up to 100%). This illustrates that the comparative approach is consistently more accurate than the ab initio one.