Question

In comparative approach to RNA structure prediction, in Dynalign program–by comparing _________ from each sequence, a ______ structure common to both sequences is selected that serves as the basis for sequence alignment.

(a) multiple alternative structures, lowest energy

(b) single structure, lowest energy

(c) single structure, highest energy

(d) multiple alternative structures, highest energy

The question was posed to me by my college professor while I was bunking the class.

My question is from Performance Evaluation topic in division RNA Structure Prediction of Bioinformatics

Answer 1

Correct answer is (a) multiple alternative structures, lowest energy

The explanation: The unique feature of this program is that it does not require sequence similarity and therefore can handle very divergent sequences. However, because of the computation complexity, the program only predicts small RNA sequences such as tRNA with reasonable accuracy.