Question

An approach for obtaining a higher-scoring MSA (Multiple Sequence Alignment) by rearranging an existing alignment uses a probability approach called simulated annealing.

(a) True

(b) False

I had been asked this question by my college professor while I was bunking the class.

I would like to ask this question from Iterative Methods of Multiple Sequence Alignment in section Multiple Sequence Alignment of Bioinformatics

Answer 1

Right choice is (a) True

The explanation is: The program MSASA (Multiple Sequence Alignment by Simulated Annealing) starts with a heuristic MSA (Multiple Sequence Alignment). Further, it changes the alignment by following an algorithm designed to identify changes that increase the alignment score.