Question

The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment.

(a) True

(b) False

The question was posed to me by my school principal while I was bunking the class.

I'd like to ask this question from Progressive Methods of Multiple Sequence Alignment topic in division Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct choice is (a) True

Explanation: As more sequences are added to a profile of an existing MSA, gaps accumulate and influence the alignment of further sequences. CLUSTALW calculates gaps in a novel way designed to place them between conserved domains.