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The algorithms used here can be classified into two categories, pairwise energy based and profile...

The algorithms used here can be classified into two categories, pairwise energy based and profile based.

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asked Sep 11, 2021 in Bioinformatics by nolan (111k points)

The algorithms used here can be classified into two categories, pairwise energy based and profile based.

(a) True

(b) False

I got this question in my homework.

The query is from Threading and Fold Recognition in section Protein Tertiary Structure Prediction of Bioinformatics

bioinformatics
protein tertiary structure prediction
threading and fold recognition

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1 Answer

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answered Sep 13, 2021 by myra (687k points)
selected Sep 13, 2021 by nolan

Best answer

The correct option is (a) True

Best explanation: The pairwise energy–based method was originally referred to as threading and the profile-based method was originally defined as fold recognition. However, the two terms are now often used interchangeably without distinction in the literature.

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In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.

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The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.

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Which of the following is untrue about profile method?

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Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.

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