Question

In ab initio methods for RNA structure prediction, the prediction results from RNAfold are not always guaranteed to be better than those predicted by Mfold.

(a) True

(b) False

I got this question in an interview.

I would like to ask this question from Comparative Approach topic in section RNA Structure Prediction of Bioinformatics

Answer 1

The correct option is (a) True

To explain I would say: Because of the much larger number of secondary structures to be computed, a more simplified energy rule has to be used to increase computational speed. Thus, the prediction results are not always guaranteed to be better than those predicted by Mfold.