Question

Conversion of acetyl co-A to malonyl co-A requires which of the following?

(a) NADPH

(b) H2O

(c) Folic acid

(d) Biotin

I had been asked this question by my school principal while I was bunking the class.

I'm obligated to ask this question of Biosynthesis of Fatty Acids and Eicosanoids topic in section Lipid Biosynthesis, Biosynthesis of Amino Acids, Nucleotides and Related Molecules of Biochemistry

Answer 1

Correct option is (d) Biotin

To elaborate: Transcarboxylase transfers activated CO2 from biotin to acetyl co-A producing malonyl co-A.