Question

Which of the following is untrue regarding the transmembrane proteins?

(a) Constitute up to 30% of all cellular proteins

(b) They are responsible for performing a wide variety of important functions in a cell, such as signal transduction, cross-membrane transport, and energy conversion

(c) The membrane proteins are also of tremendous biomedical importance

(d) They are not drug targets or receptors

I had been asked this question in exam.

This interesting question is from Secondary Structure Prediction for Transmembrane Proteins in chapter Secondary Structure Prediction of Bioinformatics

Answer 1

Right choice is (d) They are not drug targets or receptors

For explanation: The membrane proteins are also of tremendous biomedical importance, as they often serve as drug targets for pharmaceutical development. There are two types of integral membrane proteins: α-helical type and β-barrel type. Most transmembrane proteins contain solely α-helices, which are found in the cytoplasmic membrane. A few membrane proteins consist of β-strands forming a β- barrel topology, a cylindrical structure composed of antiparallel β-sheets.