Question

Which of the following is untrue regarding RNA structure?

(a) RNA structure 4.6 is a Windows implementation of the Zuker algorithm

(b) It includes additional options for other folding algorithms and incorporation of experimental data

(c) The authors of RNA structure collaborate very closely with the Turner laboratory and keep the most up-to-date thermodynamic parameters

(d) The OligoWalk program cannot be used for siRNA design

I have been asked this question in exam.

This is a very interesting question from Searching Genomes for RNA & RNA Structure Modeling Applications in chapter RNA Structure Prediction of Bioinformatics

Answer 1

Right option is (d) The OligoWalk program cannot be used for siRNA design

The best explanation: Two unique ways of incorporating experimental data in the RNA folding is done with Dynalign and chemical modification. The Dynalign program computes the lowest free-energy sequence alignment and secondary structure common to two RNA sequences.