Question

Which of the following is untrue about Vienna RNA Websuite?

(a) It introduced the Wuchty algorithm, developed applications of the McCaskill algorithm

(b) It also offers a wide variety of algorithms and functions

(c) The Wuchty algorithm generates a small but complete set of suboptimal structures

(d) The Wuchty algorithm computes some possible tertiary structures within a narrow free-energy range

This question was addressed to me in an interview.

My question is from Searching Genomes for RNA & RNA Structure Modeling Applications topic in section RNA Structure Prediction of Bioinformatics

Answer 1

Right answer is (d) The Wuchty algorithm computes some possible tertiary structures within a narrow free-energy range

The explanation is: The Wuchty algorithm computes all possible secondary structures within a narrow free-energy range. The Wuchty algorithm generates a small but complete set of suboptimal structures that may include some very different secondary structures but also very many highly similar structures. However, structures containing more than one suboptimal region may occur in the Wuchty set of structures but would be absent if the Zuker method for sampling suboptimal structures were used.