Question

One of the first methods used to find tRNA genes was to search for sequences that are complementary and can fold into a knot like the three found in tRNAs.

(a) True

(b) False

This question was addressed to me during a job interview.

The question is from Searching Genomes for RNA & RNA Structure Modeling Applications in division RNA Structure Prediction of Bioinformatics

Answer 1

Correct option is (b) False

The best explanation: One of the first methods used to find tRNA genes was to search for sequences that are self-complementary and can fold into a hairpin like the three found in tRNAs (Staden 1980). Through the regions of self-complimentarity it was first possible to find the tRNA.