Question

Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?

(a) Proteins do not operate as a complex

(b) This method detects the co-presence or co-absence of orthologs across a number of genomes

(c) Protein interactions can be predicted using phylogenetic profiles

(d) Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes

I had been asked this question in a job interview.

My question is based upon Protein Interactions in section Functional Genomics & Proteomics of Bioinformatics

Answer 1

The correct answer is (a) Proteins do not operate as a complex

For explanation I would say: The logic behind the co-occurrence approach is that proteins normally operate as a complex. If one of the components of the complex is lost, it results in the failure of the entire complex. Under the selective pressure, the rest of the nonfunctional interacting partners in the complex are also lost during evolution because they have become functionally unnecessary.