Question

Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?

(a) It is based on gene fusion events

(b) Predicting protein–protein interactions is called the “Rosetta stone” method

(c) A fused protein often reveals relationships between its domain components

(d) A fused protein doesn’t necessarily reveal about the relationships between its domain components

The question was asked during an online interview.

Asked question is from Protein Interactions in division Functional Genomics & Proteomics of Bioinformatics

Answer 1

Correct answer is (d) A fused protein doesn’t necessarily reveal about the relationships between its domain components

To elaborate: The rationale goes like this: if A and B exist as interacting domains in a fusion protein in one proteome, the gene encoding the protein is a fusion gene. Their homologous gene sequences A and B existing separately in another genome most likely encode proteins interacting to perform a common function. Conversely, if ancestral genes A and B encode interacting proteins, they may have a tendency to be fused together in other genomes during evolution to enhance their effectiveness.