Question

The signal sequences have a _________ consensus but contain some specific features. They all have a ______ core region preceded by one or more positively charged residues.

(a) weak, hydrophilic

(b) weak, hydrophobic

(c) strong, hydrophilic

(d) strong, hydrophilic

I have been asked this question during an online interview.

Origin of the question is Protein Sorting topic in section Functional Genomics & Proteomics of Bioinformatics

Answer 1

Right option is (b) weak, hydrophobic

To explain I would say: However, the length and sequence of the signal sequences vary tremendously. Peptides targeting mitochondria, for example, are located in the N-terminal region.