Question

Within-Genome Approach is to identify regions within a genome with unusual compositions.

(a) True

(b) False

I had been asked this question in a job interview.

My question comes from Comparative Genomics topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Right answer is (a) True

For explanation: Single or oligonucleotide statistics, such as G–C composition, codon bias, and oligonucleotide frequencies are used. Unusual nucleotide statistics in certain genomic regions versus the rest of the genome may help to identify “foreign” genes in a genome. A commonly used parameter is GC skew ((G − C)/(G + C)), which is compositional bias for G in a DNA sequence and is a commonly used indicator for newly acquired genetic elements.