Question

Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.

(a) True

(b) False

I got this question during an interview.

I need to ask this question from Conformational Flexibility topic in portion Predicting the Structure of Protein – Biomolecular Interactions of Bioinformatics

Answer 1

Correct choice is (b) False

To elaborate: The advantages of stochastic methods are that the ligand is able to explore conformational space in a relatively unconstrained way, frequently leading to the globally optimal solution. The disadvantages are that it cannot guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.