Question

Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.

(a) not significant

(b) only marginally significant

(c) totally significant

(d) significant to much extent

The question was asked in a national level competition.

Query is from Protein in division Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct option is (b) only marginally significant

Best explanation: In prokaryotes, genes are co-regulated if they are a member of the same operon, and many proteins that are members of the same stable complex are part of the same operon. For instance, Ouzounis and Karp determined that over 90% of the enzymes that are in stable complexes in E. coli metabolic pathways are adjacent on the E. coli chromosome.